longevity-science

an ageing, well-dressed man, mid-life, looking like he's suffering, with a headache or similar, hyper realistic, like photo

Aging Is
Fundamentally Cellular Damage

Aging isn’t just about getting older—it’s about your cells taking hits, day in and day out.

The real culprits?

  • Free radicals (aka oxidative
    stress), UV rays and environmental toxins, Inflammation, Mitochondrial
    decline, DNA damage

This constant wear and tear breaks your cells down over time—leading to wrinkles,
low energy, slower recovery, and higher risk of disease.

So how do you fight back?

It starts with NAD⁺—a vital molecule that exists in every living cell. Your body already makes it. In fact, it’s found in all living organisms. NAD⁺ is essential for:

  • Cellular energy production, DNA
    repair, Healthy metabolism, Protecting cells from stress

But there’s a problem: NAD⁺ levels decline steeply with age—dropping by up to 50% by your 40s and beyond. That decline is one of the reasons we feel the effects of aging more as time goes on.

That’s where our supplement comes in.

  • Nicotinamide Riboside (NR)

    A powerful precursor to NAD⁺, meaning your body converts it directly into the NAD⁺ it needs for energy production, repair, and longevity.

  • Resveratrol

    A polyphenol found in red wine (yes, the fun one), shown to activate sirtuins—the same cellular defense pathways supported by NAD⁺. It works synergistically with NR for deeper cellular support.

  • Quercetin

    A plant antioxidant that helps reduce inflammation and oxidative stress, while also supporting NAD⁺ recycling in the body.

Peer reviewed research papers

Nicotinamide Riboside

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans (Trammell et al., 2016, Nature Communications)

https://pubmed.ncbi.nlm.nih.gov/27721479/

Nicotinamide Riboside (NR) is a vitamin that boosts NAD+ levels in the body.

Human studies show that a single NR dose can raise blood NAD+ by up to 2.7×, with higher doses giving stronger effects.

NR works better and faster than other forms of vitamin B3, and it creates NAAD, a marker that shows NAD+ levels are successfully increased.

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Yoshino, J., Baur, J. A., & Imai, S. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism, 27(3), 513–528.
https://doi.org/10.1016/j.cmet.2018.02.011

 The Biology and Therapeutic Potential of NMN and NR.” Trends in Endocrinology & Metabolism 2018.

https://www.sciencedirect.com/science/article/pii/S1550413117306708

This landmark Cell Metabolism review shows that NAD+ is essential for metabolism, DNA repair, and longevity, but naturally declines with age. The authors found that supplementing with Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN) effectively restores NAD+ across multiple tissues, leading to improved metabolism, mitochondrial function, and insulin sensitivity. The effects were especially strong in older or metabolically impaired subjects, suggesting that maintaining NAD+ levels
through these precursors holds significant potential for promoting healthy
aging.

 Damgaard MV, Treebak JT. (2023). What is really known about the effects of nicotinamide riboside supplementation in
humans. Science Advances, 9(29): eadi4862.
https://doi.org/10.1126/sciadv.adi4862
(Damgaard et al., 2023)

Summary: Across 25 human studies,
oral NR is safe and consistently raises blood NAD⁺-related metabolites, but shows few robust, clinically meaningful effects; modest anti-inflammatory signals appear in some trials, and the authors urge larger, well-controlled studies to identify true responders.



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